Kellen J A, Chan A W, Mirakian A
Res Commun Chem Pathol Pharmacol. 1980 Nov;30(2):377-80.
Oral treatment with alpha-difluoromethyl ornithine (2.75 g/kg rat/day) simultaneous with subscapular implantation in Buffalo rats of the 5213, 1-1 hepatoma, retarded significantly the tumor growth rate for 20 days. The regimen also decreased tumor ornithine decarboxylase activity (ODC); however, the tumors growing despite treatment, maintained their malignant characteristics and ODC activity when re-transplanted into normal animals.
在布法罗大鼠肩胛下植入5213、1-1肝癌的同时，口服α-二氟甲基鸟氨酸（2.75克/千克大鼠/天），可显著延缓肿瘤生长速度达20天。该方案还降低了肿瘤鸟氨酸脱羧酶活性（ODC）；然而，尽管接受了治疗仍在生长的肿瘤，当重新移植到正常动物体内时，仍保持其恶性特征和ODC活性。
