Chakravarty P K, Ghosh A, Chowdhury J R
Chittaranjan National Cancer Institute, Calcutta, India.
Neoplasma. 1994;41(3):187-9.
The copper content and ceruloplasmin activity were determined in mice bearing benzo(a)pyrene induced fibrosarcoma. The copper level and ceruloplasmin activity in different organs of fibrosarcomatous mice varied when compared to their controls. Significant changes in copper and ceruloplasmin concentration were observed in the liver and tumor tissue of host mice bearing fibrosarcoma compared to controls. Disturbed copper metabolism at the hepatic level may account for the hypercupremia observed during malignancy.
测定了苯并(a)芘诱导的纤维肉瘤小鼠的铜含量和铜蓝蛋白活性。与对照组相比，纤维肉瘤小鼠不同器官中的铜水平和铜蓝蛋白活性有所变化。与对照组相比，携带纤维肉瘤的宿主小鼠的肝脏和肿瘤组织中铜和铜蓝蛋白浓度有显著变化。肝脏水平的铜代谢紊乱可能是恶性肿瘤期间观察到的高铜血症的原因。
