Allen S J, Dawbarn D, Eckford S D, Wilcock G K, Ashcroft M, Colebrook S M, Feeney R, MacGowan S H
Department of Medicine (Care of the Elderly), University of Bristol, Bristol Royal Infirmary, U.K.
Neuroscience. 1994 Jun;60(3):825-34. doi: 10.1016/0306-4522(94)90507-x.
A truncated form of the human trkB gene has been cloned and sequenced. This gene is related to the trk family of tyrosine kinases, the products of which act as receptors for the neurotrophins. Of these, brain-derived neurotrophic factor and mammalian neurotrophin-4 are the known ligands for the TrkB receptor. Catalytic and non-catalytic (or truncated) forms of the trkB gene have been cloned for rat and mouse. In this study, using in situ hybridization, we describe the distribution of trkB messenger RNA in fetal and adult human brain.
人类trkB基因的一种截短形式已被克隆和测序。该基因与酪氨酸激酶的trk家族相关，其产物作为神经营养因子的受体。其中，脑源性神经营养因子和哺乳动物神经营养因子-4是TrkB受体的已知配体。trkB基因的催化形式和非催化（或截短）形式已在大鼠和小鼠中克隆。在本研究中，我们使用原位杂交描述了trkB信使核糖核酸在胎儿和成人脑中的分布。
