Rinne J O, Daniel S E, Scaravilli F, Harding A E, Marsden C D
University Department of Clinical Neurology, Institute of Neurology, London, England.
Neurology. 1994 Sep;44(9):1629-32. doi: 10.1212/wnl.44.9.1629.
We counted nerve cells in different subregions of the substantia nigra in three patients with neuroacanthocytosis and compared the results with those of age-matched Parkinson's disease and control patients. Two patients with neuroacanthocytosis and clinical parkinsonism in life had a reduced neuronal density in the substantia nigra, while in a third patient without parkinsonism, this number was at the lower limit of the control range. In neuroacanthocytosis with parkinsonism and in Parkinson's disease, the ventrolateral region of the substantia nigra was most severely affected, although in neuroacanthocytosis cases, nigral neuronal loss was more widespread.
我们对3例神经棘红细胞增多症患者黑质不同亚区域的神经细胞进行了计数，并将结果与年龄匹配的帕金森病患者及对照患者的结果进行了比较。2例生前患有神经棘红细胞增多症和临床帕金森症的患者黑质神经元密度降低，而第3例无帕金森症的患者，该数值处于对照范围的下限。在伴有帕金森症的神经棘红细胞增多症和帕金森病中，黑质腹外侧区域受影响最为严重，尽管在神经棘红细胞增多症病例中，黑质神经元丢失更为广泛。
