静脉注射免疫球蛋白治疗僵人综合征。
Treatment of stiff-man syndrome with intravenous immunoglobulin.
作者信息
Amato A A, Cornman E W, Kissel J T
机构信息
Department of Neurology, Wilford Hall Medical Center, Lackland AFB, TX.
出版信息
Neurology. 1994 Sep;44(9):1652-4. doi: 10.1212/wnl.44.9.1652.
Stiff-man syndrome (SMS) is a rare disorder characterized by progressive rigidity, stiffness, and spasms of axial and extremity muscles. The etiology of SMS is unknown, but evidence suggests a possible autoimmune basis. The recent successful use of intravenous immunoglobulin (IVIG) in treating various autoimmune neuromuscular disorders led us to try IVIG in an uncontrolled pilot study on three patients. All three showed subjective and objective improvement.
僵人综合征（SMS）是一种罕见的疾病，其特征为躯干和四肢肌肉进行性僵硬、强直及痉挛。SMS的病因不明，但有证据表明可能存在自身免疫基础。近期静脉注射免疫球蛋白（IVIG）成功用于治疗各种自身免疫性神经肌肉疾病，这促使我们在一项针对三名患者的非对照试验性研究中尝试使用IVIG。所有三名患者均表现出主观和客观上的改善。
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