Marsico S, Pizzo A, Grioli M F, Scriva D
Istituto di Ginecologia, Università degli Studi di Messina.
Minerva Ginecol. 1994 May;46(5):223-33.
The Authors describe in detail the complex immunological mechanisms thanks to which the maternal organism does not reject the embryo, constituting an allogenic transplant. They examine the modifications, referring to both natural and adoptive immunity, occurring in the pregnant without ignoring the important contribution the foetus itself and adnexa make to the gestation positive termination. In the second part of the paper all the pregnancy pathologies, originating from an imbalance proper to the immunity system, are considered. The following pathologies are particularly described: a) the spontaneous recurrent abortion, both primary and secondary; b) the gestosis; c) the maternal-foetal isoimmunization towards transferable antigens present on red corpuscles, white corpuscles and blood platelets. At last Authors describe all the autoimmune illnesses in pregnancy and their influence on the foetus. Such illnesses may be: a) organ-specifics (immunological thrombocytopenic purpura, thyrotoxicosis, myxedema, serious myasthenia); b) systemics (rheumatoid arthritis, lupus erythematous). The course of each pathology, its influence on the embryo and, the present therapeutic protocols are examined.
作者详细描述了复杂的免疫机制，正是借助这些机制，母体机体不会排斥构成同种异体移植的胚胎。他们研究了妊娠期间发生的与天然免疫和过继免疫相关的变化，同时也没有忽视胎儿自身及附件对妊娠顺利结束所做出的重要贡献。在论文的第二部分，探讨了所有源于免疫系统失衡的妊娠病理情况。特别描述了以下几种病理情况：a）原发性和继发性自然复发性流产；b）妊娠中毒症；c）母体对红细胞、白细胞和血小板上存在的可转移抗原的母婴同种免疫。最后，作者描述了妊娠期间所有的自身免疫性疾病及其对胎儿的影响。这些疾病可能为：a）器官特异性疾病（免疫性血小板减少性紫癜、甲状腺毒症、黏液性水肿、重症肌无力）；b）全身性疾病（类风湿性关节炎、红斑狼疮）。研究了每种病理情况的病程、其对胚胎的影响以及当前的治疗方案。
