[Results of multiple follicular growth with CC + pure FSH + HCG and intrauterine insemination with washed semen].

The Authors have treated 40 women affected by primary or secondary infertility due to various etiologies (with the exclusion of the tubal factor as cause of infertility) for 123 cycles with clomiphene citrate (CC) 50 mg/daily/6 days from day cycle IV to/days from day cycle IX+pure follicle-stimulating hormone (FSH) 75 IU/daly from day cycle VII day cycle IX and 150 IU/d of pure follicle-stimulating hormone (FSH) from day cycle 10th to day cycle XII/XIII. In all patients human chorionic gonadotropin (HCG 5000IU) was administered when the level of 17 B-estradiol was > or = 900 pg/ml and the follicular diameter > or = 19 mm. After 24 hours from the administration of human chorionic gonadotropins (HCG), the patients underwent intrauterine insemination with washed semen and the insemination was repeated in all patients 24 hours after the first-one. This protocol has allowed to obtain 12 pregnancies (30%); the cancelled cycles were 9 (of whom 5, equal to 4.06%, for mild hyperstimulation and 4, equal to 3.25%, for non compliance). Our results confirm the value of the protocol and the low risk of ovarian hyperstimulation following the use of pure follicle-stimulating hormone (FSH) in association with clomiphene citrate (CC).