Nardo F, D'Agosta S, Bellanca S A, Bonanno A M
Rev Fr Gynecol Obstet. 1994 Jul-Sep;89(7-9):382-6.
The authors used multiple ovulation induction by CC+hMG+hCG and intrauterine insemination with capacitized sperm in 63 women, aged between 22 and 43 (mean age 32.474 +/- 5.364) with primary or secondary infertility of various origins (tubal problems being excluded) to enhance the chances of pregnancy and evaluate the pregnancy rate. Partners were aged between 26 and 47 (mean age 36.571 +/- 6.709). The following parameters were considered in all patients: mean age of the partners of the couple, parity, seminal fluid characteristics, duration of infertility, dose of each drug administered, mean number of ampuls per patient and mean 17 beta-estradiol level at the time of administration of hCG. There were 189 cycles induced and 26 suspended (13.75%) including 7 (3.70%) because of protocol drop-out, 13 (6.87%) because of the development of slight hyperstimulation and 6 (3.17%) because of marked hyperstimulation. There were 27 pregnancies (42.85%), 4 of which ended in miscarriage between 7 and 10 weeks. There were 4 twin pregnancies, i.e. 14.81%. Of the 27 pregnancies, 13 (48.14%) were obtained during the first cycle, 9 (33.33%) during the second cycle and 5 (18.51%) during the 3rd cycle. The rate of pregnancies per cycle was 14.89%. With regard to 17 beta-estradiol levels at the time of administration of hCG, 18 pregnancies (69.23%) were obtained in patients with a 17 beta-estradiol level > or = to 1300, 7 (25.92%) in patients with a 17 beta-estradiol level > or = to 1000 and < or = to 1300 pg/ml and 3 (11.11%) in those with a 17 beta-estradiol level < or = to 900 pg/ml.
作者对63名年龄在22至43岁（平均年龄32.474±5.364岁）、患有各种原因导致的原发性或继发性不孕症（排除输卵管问题）的女性，采用克罗米芬（CC）+人绝经期促性腺激素（hMG）+人绒毛膜促性腺激素（hCG）进行多次排卵诱导，并使用获能精子进行宫内授精，以提高妊娠几率并评估妊娠率。伴侣年龄在26至47岁之间（平均年龄36.571±6.709岁）。所有患者均考虑以下参数：夫妻双方伴侣的平均年龄、产次、精液特征、不孕持续时间、每种药物的给药剂量、每位患者的平均安瓿数量以及注射hCG时的平均17β-雌二醇水平。共诱导了189个周期，其中26个周期中止（13.75%），包括因方案退出中止7个周期（3.70%）、因轻度卵巢过度刺激综合征发展中止13个周期（6.87%）以及因重度卵巢过度刺激综合征中止6个周期（3.17%）。共有27例妊娠（42.85%），其中4例在7至10周时流产。有4例双胎妊娠，即14.81%。在这27例妊娠中，13例（48.14%）在第一个周期获得，9例（33.33%）在第二个周期获得，5例（18.51%）在第三个周期获得。每个周期的妊娠率为14.89%。关于注射hCG时的17β-雌二醇水平，17β-雌二醇水平≥1300的患者中有18例妊娠（69.23%），17β-雌二醇水平≥1000且≤1300 pg/ml的患者中有7例妊娠（25.92%），17β-雌二醇水平≤900 pg/ml的患者中有3例妊娠（11.11%）。
