[Results of intrauterine insemination after induction of multiple follicular growth].

The authors used multiple ovulation induction by CC+hMG+hCG and intrauterine insemination with capacitized sperm in 63 women, aged between 22 and 43 (mean age 32.474 +/- 5.364) with primary or secondary infertility of various origins (tubal problems being excluded) to enhance the chances of pregnancy and evaluate the pregnancy rate. Partners were aged between 26 and 47 (mean age 36.571 +/- 6.709). The following parameters were considered in all patients: mean age of the partners of the couple, parity, seminal fluid characteristics, duration of infertility, dose of each drug administered, mean number of ampuls per patient and mean 17 beta-estradiol level at the time of administration of hCG. There were 189 cycles induced and 26 suspended (13.75%) including 7 (3.70%) because of protocol drop-out, 13 (6.87%) because of the development of slight hyperstimulation and 6 (3.17%) because of marked hyperstimulation. There were 27 pregnancies (42.85%), 4 of which ended in miscarriage between 7 and 10 weeks. There were 4 twin pregnancies, i.e. 14.81%. Of the 27 pregnancies, 13 (48.14%) were obtained during the first cycle, 9 (33.33%) during the second cycle and 5 (18.51%) during the 3rd cycle. The rate of pregnancies per cycle was 14.89%. With regard to 17 beta-estradiol levels at the time of administration of hCG, 18 pregnancies (69.23%) were obtained in patients with a 17 beta-estradiol level > or = to 1300, 7 (25.92%) in patients with a 17 beta-estradiol level > or = to 1000 and < or = to 1300 pg/ml and 3 (11.11%) in those with a 17 beta-estradiol level < or = to 900 pg/ml.