Vigliani R, Galliano D, Iandolo M
Servizio di Anatomia e Istologia Patologica, Ospedale E. Agnelli, USL 44, Pinerolo.
Pathologica. 1994 Apr;86(2):206-10.
An occasional finding of a signet-ring cell type adenoma, occurring in a 81-year-old man, suffering from inoperable pharyngo-laryngeal carcinoma, is described. Multinodular thyroid parenchyma was excided in performing tracheostomy and histologically examined. On the basis of extensive morphological, histochemical and immunohistochemical observations and of reviewed literature, an unifying morphogenetic interpretation of the signet-ring cell transformation is proposed, with special reference to the pathogenesis of this cytotype and the significance of the cytostructural and cytometabolic characteristics. Problems related to the differential diagnosis and clinicopathological correlation are also discussed.
本文描述了一例偶然发现的印戒细胞型腺瘤，患者为一名81岁男性，患有无法手术的咽喉癌。在进行气管切开术时切除了多结节性甲状腺实质并进行了组织学检查。基于广泛的形态学、组织化学和免疫组织化学观察以及文献复习，提出了印戒细胞转变的统一形态发生学解释，特别提及了这种细胞类型的发病机制以及细胞结构和细胞代谢特征的意义。还讨论了与鉴别诊断和临床病理相关性相关的问题。
