Kogutt M S, Goldwag S S, Gupta K L, Kaneko K, Humbert J R
Department of Radiology, Tulane University Medical Center, New Orleans, LA 70112-2699.
Pediatr Radiol. 1994;24(3):204-6. doi: 10.1007/BF02012192.
We prospectively evaluated a group of patients with sickle cell disease and a clinical history of prior stroke, comparing transcranial Doppler sonography (TCD) to both magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) to determine its efficacy for the detection of flow abnormalities associated with prior cerebral infarction. Using MRI as the standard examination, there was 94% sensitivity and 30% specificity, and using MRA as the standard examination, there was 91% sensitivity and 22% specificity. We concur with other reports that the transcranial Doppler examination is a highly sensitive study. In our group of sickle cell disease patients with prior stroke, TCD reliably detected flow abnormalities that correlated to areas of prior cerebral infarction.
我们前瞻性地评估了一组患有镰状细胞病且有既往中风临床病史的患者，将经颅多普勒超声（TCD）与磁共振成像（MRI）和磁共振血管造影（MRA）进行比较，以确定其检测与既往脑梗死相关的血流异常的功效。以MRI作为标准检查时，敏感性为94%，特异性为30%；以MRA作为标准检查时，敏感性为91%，特异性为22%。我们赞同其他报告的观点，即经颅多普勒检查是一项高度敏感的研究。在我们这组有既往中风的镰状细胞病患者中，TCD可靠地检测到了与既往脑梗死区域相关的血流异常。
