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引用本文的文献

1
Improved statistical methods reveal direct interactions between 16S and 23S rRNA.改进的统计方法揭示了16S和23S核糖体RNA之间的直接相互作用。
Nucleic Acids Res. 2000 Dec 15;28(24):4938-43. doi: 10.1093/nar/28.24.4938.

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STRUCTURE OF A RIBONUCLEIC ACID.核糖核酸的结构
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系统发育上保守的核糖体RNA碱基对：参与核糖体亚基的结合

Phylogenetically preserved inter-rRNA base pairs: involvement in ribosomal subunit association.

作者信息

Thanaraj T A

机构信息

Centre for Cellular and Molecular Biology, Hyderabad, India.

出版信息

Nucleic Acids Res. 1994 Sep 25;22(19):3936-42. doi: 10.1093/nar/22.19.3936.

DOI:10.1093/nar/22.19.3936
PMID:7937116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC308393/
Abstract

Intermolecular complementary base pairs, that can be formed between the bases from single-stranded and weak stem regions on 16S rRNA and those on 23S rRNA, were located and checked for preservation in a variety of species covering the complete phylogenetic spectrum. Putative base pairs that exhibited two 'compensatory base pair changes' (a requisite as dictated by the approach of 'comparative sequence data analysis') were picked up. Potential base pairs were selected by assessing the frequency and taxonomy specificity of the occurrence of compensatory base pair changes against those of other types of base pair changes. The selected base pairs were classified as universal, non-mitochondrial, and prokaryote-specific. The positions of the proposed base pairs occur near the structurally and functionally important regions on rRNAs.

摘要

位于16S rRNA和23S rRNA单链及弱茎区的碱基之间能够形成的分子间互补碱基对，在涵盖整个系统发育谱系的各种物种中进行了定位并检查其保守性。挑选出呈现两个“补偿性碱基对变化”（这是“比较序列数据分析”方法所规定的必要条件）的假定碱基对。通过评估补偿性碱基对变化相对于其他类型碱基对变化的出现频率和分类特异性来选择潜在碱基对。所选碱基对被分类为通用型、非线粒体型和原核生物特异性型。所提出的碱基对位置位于rRNA上结构和功能重要区域附近。