长期血管紧张素转换酶抑制剂治疗对轻至中度心力衰竭患者动脉血氧饱和度的影响。
Effect of long-term angiotensin-converting enzyme inhibitor therapy on arterial oxygen saturation in patients with mild to moderate heart failure.
作者信息
Stanek E J, Nara A R, Strohl K P, Nair R N, Decker M J, Munger M A
机构信息
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy and Science, PA 19104.
出版信息
Pharmacotherapy. 1994 May-Jun;14(3):321-9.
STUDY OBJECTIVE
To evaluate the effects of angiotensin-converting enzyme (ACE) inhibition on continuous pulse oximetry recordings of arterial oxygen saturation (SpO2).
DESIGN
Open-label study.
SETTING
Cardiology clinics at two large teaching hospitals.
PATIENTS
Eight patients with New York Heart Association Functional Class (NYHA FC) II-III heart failure.
INTERVENTIONS
Patients were studied after an ACE inhibitor washout (baseline, B), and after 3 months following resumption of therapy (ACE).
MEASUREMENTS AND MAIN RESULTS
Monitoring times for B and ACEI were approximately 22 hours. Reduction trends were observed for number (190 +/- 170 vs 125 +/- 67 B vs ACEI), magnitude (8.2 +/- 1.4% vs 7.5 +/- 1.8%), and duration (2.45 +/- 2.8 vs 1.35 +/- 0.8 min) of desaturations/monitoring period, and for nadir SpO2/desaturation (88.1 +/- 1.5% vs 89.9 +/- 3.3%). The B desaturation index [(cumulative desaturation time/monitoring period time) x 100, a measure of hypoxic stress or burden] decreased from 19.4 +/- 8.1% to 11.9 +/- 8.1% at ACEI (p = 0.024).
CONCLUSION
Long-term ACE inhibitor therapy improves the profile of SpO2 values over time in patients with NYHA FC II-III heart failure.
研究目的
评估血管紧张素转换酶（ACE）抑制对动脉血氧饱和度（SpO2）连续脉搏血氧饱和度记录的影响。
设计
开放标签研究。
地点
两家大型教学医院的心脏病诊所。
患者
8例纽约心脏协会功能分级（NYHA FC）II - III级心力衰竭患者。
干预措施
患者在停用ACE抑制剂后（基线，B）以及恢复治疗3个月后（ACE）接受研究。
测量指标及主要结果
B期和ACEI期的监测时间约为22小时。观察到每监测期的血氧饱和度下降次数（190±170次对125±67次，B期对ACEI期）、下降幅度（8.2±1.4%对7.5±1.8%）和持续时间（2.45±2.8分钟对1.35±0.8分钟）以及最低SpO2/血氧饱和度下降情况（88.1±1.5%对89.9±3.3%）均呈下降趋势。B期的血氧饱和度下降指数[（累积血氧饱和度下降时间/监测期时间）×100，衡量缺氧应激或负担的指标]在ACEI期从19.4±8.1%降至11.9±8.1%（p = 0.024）。
结论
长期ACE抑制剂治疗可改善NYHA FC II - III级心力衰竭患者随时间变化的SpO2值情况。
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