Fernandez-Miranda C, Mateo S, Gonzalez-Gomez C, Ballestin C
Department of Medicine and Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Postgrad Med J. 1994 Jul;70(825):505-6. doi: 10.1136/pgmj.70.825.505.
A case of ovarian carcinoma and systemic amyloidosis in a 64 year old woman with nephrotic syndrome is reported. Immunohistochemical study of renal and rectal biopsy specimens revealed the presence of amyloidosis AA antigens, consistent with secondary amyloidosis. The absence of chronic inflammatory or infectious disease suggested the presence of a neoplasm. The gynaecological sonogram showed a solid mass located behind the uterus. Laparotomy confirmed a poorly differentiated ovarian carcinoma. The association of systemic amyloidosis and ovarian carcinoma has not to our knowledge been described previously.
报告了一例64岁患有肾病综合征的女性卵巢癌合并系统性淀粉样变病例。对肾和直肠活检标本进行免疫组织化学研究发现存在淀粉样变AA抗原，符合继发性淀粉样变。无慢性炎症或感染性疾病提示存在肿瘤。妇科超声检查显示子宫后方有一实性肿块。剖腹手术证实为低分化卵巢癌。据我们所知，系统性淀粉样变与卵巢癌的关联此前尚未见报道。
