Nestor K E, Bacon W L
Department of Poultry Science, Ohio Agricultural Research and Development Center, Ohio State University, Wooster 44691.
Poult Sci. 1994 Jul;73(7):947-52. doi: 10.3382/ps.0730947.
The purpose of this investigation was to study the incidence and size of smooth muscle tumors in several Japanese quail lines and to report recent correlated changes in mature BW and egg production. Laying females from lines selected solely (HW) or partly (HW-HP; HW-LP) for increased 4-wk BW or for decreased 4-wk BW (LW) and from the corresponding randombred control (R1) were used. Lines HW-HP and HW-LP were sublines of Line HW in which males were selected for increased 4-wk BW and females were selected for high or low level of total plasma phosphorus, respectively. Laying hens were examined for the presence of smooth muscle tumors after about 170 d of egg production (240 d of age). During Generations 19 through 26, mature BW was increasing in the HW line and decreasing in the LW line. Selection for either increased or decreased 4-wk BW resulted in decreased egg production, but the only significant change with generations was a decrease of 2.7 eggs per hen for a 120-d laying period in the LW line. Frequency and weight of the smooth muscle tumors were greater for females from the large-bodied lines than females from Line R1. No tumors were detected in LW females. Based on the linear regression of response on generations, tumor frequency was increasing in Line HW-LP but tumor weight was decreasing in this line. Tumor weight was increasing in the HW line. No other changes in tumor frequency or size were noted across generations. Weight of the tumors was not correlated with egg production. The presence of tumors did not seem to affect mortality during the laying period. The Japanese quail lines may serve as a useful animal model for the study of smooth muscle tumors in humans, chickens, and turkeys.
本研究的目的是调查几种日本鹌鹑品系中平滑肌肿瘤的发生率和大小，并报告成熟体重和产蛋量最近的相关变化。使用了仅根据4周龄体重增加（HW）或部分根据4周龄体重增加（HW-HP；HW-LP）或4周龄体重降低（LW）选择的品系的产蛋雌性鹌鹑，以及相应的随机交配对照（R1）。HW-HP和HW-LP品系是HW品系的亚系，其中雄性根据4周龄体重增加进行选择，雌性分别根据血浆总磷的高水平或低水平进行选择。在产蛋约170天（240日龄）后，对产蛋母鸡进行平滑肌肿瘤检查。在第19代至第26代期间，HW品系的成熟体重增加，LW品系的成熟体重降低。选择增加或降低4周龄体重都会导致产蛋量下降，但随着代次的变化，唯一显著的变化是LW品系在120天产蛋期内每只母鸡的产蛋量减少了2.7枚。大体型品系的雌性鹌鹑的平滑肌肿瘤频率和重量高于R1品系的雌性鹌鹑。在LW品系的雌性鹌鹑中未检测到肿瘤。根据反应与代次的线性回归，HW-LP品系的肿瘤频率在增加，但该品系的肿瘤重量在下降。HW品系的肿瘤重量在增加。各代之间未观察到肿瘤频率或大小的其他变化。肿瘤重量与产蛋量无关。肿瘤的存在似乎不影响产蛋期的死亡率。日本鹌鹑品系可作为研究人类、鸡和火鸡平滑肌肿瘤的有用动物模型。
