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[脑淀粉样血管病]

[Cerebral amyloid angiopathy].

作者信息

Dubas F

机构信息

Service de Neurologie A et INSERM U.298, CHU, Angers.

出版信息

Presse Med. 1994 May 28;23(20):948-50.

PMID:7937633
Abstract

The most usual form of cerebral amyloid angiopathy is due to deposition of B protein on vessel walls. This senile angiopathy is often, but inconstantly, associated with Alzheimer's disease, and rarely causes intracerebral hemorrhage, which is typically lobar and recurrent, occurring in elderly normotensive patients with ou without dementia. There is probably no cause-effect relationship between senile cerebral amyloid angiopathy and Alzheimer's disease, which may occur independently and seems to represent two modalities of cerebral amyloidosis. Other forms of cerebral amyloid angiopathy are exceptional: hereditary cerebral hemorrhages with amyloidosis differ from each another in type of fibrillar protein (cystatine-C, variant of B protein, transthyretine).

摘要

脑淀粉样血管病最常见的形式是β蛋白在血管壁沉积所致。这种老年血管病常(但并非始终)与阿尔茨海默病相关,很少引起脑出血,脑出血通常为叶性且反复发生,见于老年血压正常的患者,无论有无痴呆。老年脑淀粉样血管病与阿尔茨海默病之间可能不存在因果关系,它们可能独立发生,似乎代表了脑淀粉样变性的两种形式。其他形式的脑淀粉样血管病较为罕见:遗传性淀粉样变性脑出血在纤维状蛋白类型(胱抑素C、β蛋白变体、转甲状腺素蛋白)上彼此不同。

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