Vinogradova T I
Probl Tuberk. 1994(3):59-62.
The experimental studies have provided strong evidence that the efficacy of etiotropic therapy for tuberculosis can be enhanced by applying a number of antimicrobial agents having different mechanism of action, which belong to cephalosporins, macrolides, aminoglycosides, fluoroquinolones. The basis of the mechanism responsible for potentiation of activity of essential tuberculostatic drugs for potentiation of activity of essential tuberculostatic drugs is enhanced inhibition of the viability of a microbacterial population, prevented development of drug resistance in tuberculosis mycobacteria, and increased function of macrophages.
实验研究提供了强有力的证据，表明通过应用多种作用机制不同的抗菌药物（属于头孢菌素类、大环内酯类、氨基糖苷类、氟喹诺酮类），可以提高针对结核病的病因疗法的疗效。增强基本抗结核药物活性的机制基础是增强对微生物群体生存能力的抑制、防止结核分枝杆菌产生耐药性以及增强巨噬细胞功能。
