Aleksandrova A E, Vinogradova T I
Probl Tuberk. 1996(2):43-5.
Mice with experimental tuberculosis were given isoniazid, rifampicin, erythromycin, cefotaxime, ofloxacin. Erythromycin, cefotaxime and ofloxacin enhanced macrophage activity if their course did not exceed 2-4 weeks. Isoniazid and rifampicin for a short time inhibited macrophage activity then stimulated it. These findings led the authors to the conclusion that erythromycin, cefotaxime and ofloxacin must be used only in short courses.
给患有实验性肺结核的小鼠使用异烟肼、利福平、红霉素、头孢噻肟、氧氟沙星。如果使用疗程不超过2 - 4周，红霉素、头孢噻肟和氧氟沙星会增强巨噬细胞活性。异烟肼和利福平短期内会抑制巨噬细胞活性，然后刺激其活性。这些发现使作者得出结论，红霉素、头孢噻肟和氧氟沙星必须仅短期使用。
