Ohsawa M, Kanno H, Naka N, Aozasa K
Department of Pathology, Osaka University School of Medicine, Japan.
Mod Pathol. 1994 Jun;7(5):540-3.
The nature and frequency of occurrence of monocytoid B-lymphocytes (MBL) was examined in 118 cases of Hodgkin's disease. Monocytoid cells were present in six cases (5%), four nodular sclerosis and two mixed cellularity. These cells were CD20+, CD3-, CD45RO-, KP-1-, PGM1-, with occasional positive reaction for MB-1 and CD74, indicating their B-cell nature, i.e., MBL. The MBL were distributed in the periphery of the nodules of nodular sclerosis accompanying centrally located Reed-Sternberg cells, although Reed-Sternberg cells were observed in some MBL clusters. In the mixed cellularity, MBL were located in the para-follicular area occasionally adjoining the lymph follicles. Because previous studies suggested depressed immune function in autoimmune diseases, acquired immune deficiency syndrome, and older persons to be responsible for the occurrence of MBL, it is possible that in some patients development of foci of MBL under immunodeficient conditions progresses to Hodgkin's disease.
在118例霍奇金淋巴瘤患者中，对单核细胞样B淋巴细胞（MBL）的性质和出现频率进行了研究。6例（5%）存在单核细胞样细胞，其中4例为结节硬化型，2例为混合细胞型。这些细胞CD20阳性、CD3阴性、CD45RO阴性、KP-1阴性、PGM1阴性，偶尔对MB-1和CD74呈阳性反应，表明其B细胞性质，即MBL。在结节硬化型中，MBL分布于结节周边，伴有位于中央的里德-施特恩贝格细胞，尽管在一些MBL簇中也观察到了里德-施特恩贝格细胞。在混合细胞型中，MBL位于副滤泡区，偶尔毗邻淋巴滤泡。由于先前的研究表明自身免疫性疾病、获得性免疫缺陷综合征和老年人的免疫功能低下是MBL发生的原因，因此在某些患者中，免疫缺陷条件下MBL病灶的发展有可能进展为霍奇金淋巴瘤。
