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Effect of opioid peptide antisera on nitrous oxide antinociception in rats.

作者信息

Hara S, Gagnon M J, Quock R M, Shibuya T

机构信息

Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford 61107.

出版信息

Pharmacol Biochem Behav. 1994 Jul;48(3):699-702. doi: 10.1016/0091-3057(94)90335-2.

DOI:10.1016/0091-3057(94)90335-2
PMID:7938124
Abstract

This study was performed to examine the effects of ICV injection of antiserum against beta-endorphin (beta-EP) or methionine-enkephalin (ME) on nitrous oxide-induced antinociception in rats using the hot plate test. The injection of beta-EP antiserum reversed the antinociceptive effect of nitrous oxide in a dose-related manner up to 200 micrograms/rat. However, antagonism of nitrous oxide by 400 micrograms beta-EP antiserum was comparable to that produced by 200 micrograms. On the other hand, similar amounts of ME antiserum had little effect against nitrous oxide antinociception. These findings suggest that beta-EP may play an important role in the antinociceptive effect of nitrous oxide.

摘要

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