Morales M A, Lozoya X
Pharmacology Department, Faculty of Medicine, Universidad de Chile, Santiago.
Planta Med. 1994 Aug;60(4):313-7. doi: 10.1055/s-2006-959491.
Relaxation induced by quercetin was studied on aortic rings depolarized with KCl and on Ca2+ dependent aortic contraction. Quercetin's actions as a cyclooxygenase inhibitor were compared with those of indomethacin. To determine the possible effects of quercetin on internal Ca2+ mobilization, it was assayed on aortic muscle contracted with caffeine. Quercetin relaxes aortic smooth muscle contracted with KCl (RC50 = 1.8 x 10(-4) M) and induces a rightward displacement of Ca2+ curves. The relaxation induced by quercetin is higher than that produced by indomethacin, suggesting that its action is independent of cyclooxygenase inhibition. Caffeine-induced aortic contraction was not modified by quercetin, suggesting that its effect should not involve internal calcium modulation. Our results further support the thesis that the spasmolytic action of quercetin arises from its negative modulation of calcium entry to the smooth muscle.
研究了槲皮素对用氯化钾去极化的主动脉环以及对钙离子依赖性主动脉收缩的舒张作用。将槲皮素作为环氧化酶抑制剂的作用与吲哚美辛的作用进行了比较。为了确定槲皮素对细胞内钙离子动员的可能影响，在咖啡因收缩的主动脉肌上进行了测定。槲皮素可使由氯化钾收缩的主动脉平滑肌舒张（半数舒张浓度RC50 = 1.8×10⁻⁴ M），并使钙离子曲线向右移位。槲皮素诱导的舒张作用高于吲哚美辛产生的舒张作用，这表明其作用独立于环氧化酶抑制。槲皮素未改变咖啡因诱导的主动脉收缩，这表明其作用不应涉及细胞内钙调节。我们的结果进一步支持了以下论点，即槲皮素的解痉作用源于其对平滑肌钙内流的负调节。
