Del Llano A M, Lavergne J A
Department of Biology, Humacao Campus, University of Puerto Rico.
P R Health Sci J. 1994 Jun;13(2):79-124.
This work reviews the suggested mechanisms which result in programmed cell death in human HIV infection. Here we present state-of-the-art scientific information related to the newly rediscovered phenomenon of Apoptosis, and to its biological relevance in the pathogenesis of HIV disease. General features of this phenomenon are reviewed, as well as available evidence for its occurrence and possible role in AIDS pathogenesis. A complex series of cellular and molecular events leading to cellular apoptosis are also reviewed and discussed. They include events which take place at the cell membrane level and those which occur at the intramembrane level and cytoplasmic locations, which result from the immunological activation of affected cells. Cellular events which follow and occur within the mitochondrial space and at the nuclear level are also discussed. The biological significance of all these phenomena is summarized in a theoretical scheme, which attempts to integrate all cellular events leading a primed cell into its HIV-induced programmed death.
这项工作回顾了人类HIV感染中导致程序性细胞死亡的推测机制。在此，我们展示了与新发现的细胞凋亡现象及其在HIV疾病发病机制中的生物学相关性相关的前沿科学信息。本文回顾了这一现象的一般特征，以及其发生的现有证据及其在艾滋病发病机制中的可能作用。还对导致细胞凋亡的一系列复杂的细胞和分子事件进行了回顾和讨论。它们包括在细胞膜水平发生的事件以及在膜内水平和细胞质位置发生的事件，这些事件是受影响细胞免疫激活的结果。还讨论了在线粒体空间和核水平随后发生的细胞事件。所有这些现象的生物学意义在一个理论框架中进行了总结，该框架试图整合所有导致初始细胞进入HIV诱导的程序性死亡的细胞事件。
