[Lipid metabolism abnormalities and atherosclerosis in patients on maintenance hemodialysis].

Cardiovascular disease is the leading cause of death in maintenance hemodialyzed patients with end-stage chronic renal failure. Lipid abnormalities have been identified as significant risk factors for the development of premature atherosclerosis in such patients. These abnormalities include significant elevations of serum triglycerides and triglyceride-rich lipoproteins (VLDL, IDL, remnant particles), Ip(a), decrease in LDL and HDL, accompanied by changes in apolipoprotein content. The article reviews quantitative and qualitative changes in lipoprotein composition and their possible pathogenesis. The role of such changes in atherogenesis is also discussed.