Musiał J, Undas A, Sysło K
II Katedry Chorób Wewnetrznych, Collegium Medicum Uniwersytetu, Jagiellońskiego, Krakowie.
Przegl Lek. 1994;51(6):264-7.
Cardiovascular disease is the leading cause of death in maintenance hemodialyzed patients with end-stage chronic renal failure. Lipid abnormalities have been identified as significant risk factors for the development of premature atherosclerosis in such patients. These abnormalities include significant elevations of serum triglycerides and triglyceride-rich lipoproteins (VLDL, IDL, remnant particles), Ip(a), decrease in LDL and HDL, accompanied by changes in apolipoprotein content. The article reviews quantitative and qualitative changes in lipoprotein composition and their possible pathogenesis. The role of such changes in atherogenesis is also discussed.
心血管疾病是维持性血液透析的终末期慢性肾衰竭患者的主要死因。脂质异常已被确认为这类患者过早发生动脉粥样硬化的重要危险因素。这些异常包括血清甘油三酯和富含甘油三酯的脂蛋白（极低密度脂蛋白、中间密度脂蛋白、残余颗粒）、脂蛋白(a)显著升高，低密度脂蛋白和高密度脂蛋白降低，同时伴有载脂蛋白含量的变化。本文综述了脂蛋白组成的定量和定性变化及其可能的发病机制。还讨论了这些变化在动脉粥样硬化形成中的作用。
