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[对17例II期勒里什和方丹下肢闭塞性动脉疾病患者进行动态经皮血氧饱和度测定的随访研究]

[Follow-up study, using dynamic transcutaneous oximetry in 17 patients with stage II Leriche and Fontaine occlusive arterial disease of the lower limbs].

作者信息

Grard C, Perez-Cousin M, Desmyttère J, Alsberghe M C, Hachulla E, Copin D, Roux J P, Brouillard M, Hatron P Y, Warembourg H

机构信息

Service de médecine interne, CHRU, hôpital Claude-Huriez, Lille.

出版信息

Rev Med Interne. 1994;15(8):510-4. doi: 10.1016/s0248-8663(05)81480-8.

Abstract

We evaluated the value of dynamic transcutaneous oxygen pressure measurement (TcPO2) in 17 patients with stage II occlusive arterial disease of the lower limbs treated with exercise only. We studied 17 patients (15 men, two women) with an average age of 63 years (range 39-80 years). Claudication perimeter and dynamic TcPO2 were evaluated before and after 6 month walking exercise and tabac stopping. Four different sites of TcPO2 were studied: precordium (reference probe), thigh, calf and foot in the dorsal recumbent position after 30 minutes rest, during a standardised exercise stress test at 50 watts and during the recovery phase. The results were expressed as ratio of tissue oxygenation (RTO): thigh, calf or foot TcPO2/precordial TcPO2 x 100 in order to take into account the patients cardiorespiratory status and adaptation to exercise. Claudication perimeter was 255 m +/- 221 before 6 months exercise and 835 m +/- 539 after (P < 0.01). The duration of significative ischemia was significantly reduced after 6 months exercise (P = 0.02 calf, P < 0.01 foot). Dynamic transcutaneous oxymetry would therefore seem to be a useful method of assessing stage II occlusive peripheral arterial disease and the topography of tissue hypoxia. It could be valuable in orientating treatment and the first method to provide and objective evaluation of the efficacy of medical or surgical treatment.

摘要

我们评估了动态经皮氧分压测量(TcPO2)在17例仅接受运动治疗的下肢II期闭塞性动脉疾病患者中的价值。我们研究了17例患者(15例男性,2例女性),平均年龄63岁(范围39 - 80岁)。在6个月的步行锻炼和戒烟前后,评估了跛行周长和动态TcPO2。研究了TcPO2的四个不同部位:心前区(参考探头)、大腿、小腿和足部,分别在休息30分钟后仰卧位、50瓦标准化运动应激试验期间以及恢复阶段进行测量。结果以组织氧合比(RTO)表示:大腿、小腿或足部的TcPO2/心前区TcPO2×100,以便考虑患者的心肺状况和对运动的适应性。运动前6个月跛行周长为255 m±221,运动后为835 m±539(P < 0.01)。运动6个月后,明显缺血的持续时间显著缩短(小腿P = 0.02,足部P < 0.01)。因此,动态经皮血氧测定似乎是评估II期闭塞性外周动脉疾病和组织缺氧部位的一种有用方法。它在指导治疗方面可能具有价值,并且是对药物或手术治疗效果进行客观评估的首要方法。

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