de Pree C, Schifferli J A, Masouye I, Bernard P
Clinique médicale, Hôpital cantonal universitaire de Genève.
Schweiz Rundsch Med Prax. 1994 Aug 30;83(35):975-9.
Schoenlein-Henoch purpura is characterized clinically by palpable purpura, mainly on the legs, with varying degrees of gastrointestinal, articular and renal involvement. Renal involvement is often more severe in the adult than in children and it often determines the outcome of the disease. Schoenlein-Henoch purpura is also characterized by an IgA-vasculitis, which may be triggered by several non-specific antigenic factors. Its pathogenesis is still unclear, but a dysfunction of the IgA immune system has been demonstrated. We discuss the anatomo-clinical, therapeutic and etiopathogenic aspects of this syndrome according to today's knowledge.
过敏性紫癜临床特征为可触及的紫癜，主要位于双下肢，伴有不同程度的胃肠道、关节及肾脏受累。成人的肾脏受累通常比儿童更严重，且常常决定疾病的转归。过敏性紫癜还以IgA血管炎为特征，可能由多种非特异性抗原因素触发。其发病机制尚不清楚，但已证实存在IgA免疫系统功能障碍。我们根据目前的知识讨论该综合征的解剖临床、治疗及病因方面的问题。
