Eidt S, Stolte M
Institute of Pathology, University of Cologne, Germany.
Scand J Gastroenterol. 1994 Jul;29(7):607-10. doi: 10.3109/00365529409092480.
The prevalence of intestinal metaplasia (IM) in underlying Helicobacter pylori gastritis was studied in 1446 patients.
Antral and body mucosa biopsy specimens (stains: hematoxylin and eosin, Warthin-Starry) were taken from five groups of patients: gastritis with no lesions, gastritis with duodenal, pyloric, or gastric ulcers or with chronic antral erosions.
The prevalence of IM was higher in the antral than in the body mucosa (22.9% versus 2.8%; p < 0.001). Patients with IM had a higher mean age than those without IM in the overall group (p < 0.01). IM could be detected with the highest frequency in patients with gastric ulcers (p < 0.001).
The higher prevalence of IM in the antral mucosa--the preferred location of gastric carcinomas--further supports the postulated association of H. pylori and gastric carcinoma. The various prevalences of IM might contribute to explaining the different probabilities of gastric carcinoma developing in the groups investigated.
对1446例患者潜在幽门螺杆菌胃炎中肠化生（IM）的患病率进行了研究。
从五组患者中获取胃窦和胃体黏膜活检标本（染色：苏木精和伊红、Warthin-Starry）：无病变的胃炎、伴有十二指肠溃疡、幽门溃疡或胃溃疡或慢性胃窦糜烂的胃炎。
胃窦部IM的患病率高于胃体黏膜（22.9%对2.8%；p<0.001）。总体组中，有IM的患者平均年龄高于无IM的患者（p<0.01）。胃溃疡患者中IM的检出频率最高（p<0.001）。
IM在胃窦部（胃癌的好发部位）的较高患病率进一步支持了幽门螺杆菌与胃癌之间的假定关联。IM的不同患病率可能有助于解释所研究组中胃癌发生的不同概率。
