[全身辐射暴露后临床前驱症状对剂量估计的意义]
[The significance of clinical prodromes for dosage estimation after whole-body radiation exposure].
作者信息
Hartmann A, Bojar H, Zamboglou N, Pape H, Schnabel T, Schmitt G
机构信息
Klinik für Strahlentherapie und Radioonkologie, Universität Düsseldorf.
出版信息
Strahlenther Onkol. 1994 Sep;170(9):538-44.
BACKGROUND
The triage of victims after radiation injury is complicated by missing dose values and the fact that most tissues react after a latency period.
PATIENTS AND METHODS
We evaluated 63 patients undergoing total body irradiation as conditioning regime before bone marrow transplantation in order to find a relation between prodromal symptoms and dose.
RESULTS
Emesis after radiation exposure hints to doses greater than 1.5 Gy. A rise of body temperature above 37 degrees C up to five hours after exposure is related to doses exceeding 2.5 Gy, while an acute onset of diarrhoea is an indicator of a severe accident with more than 9 Gy.
CONCLUSION
Besides blood counts and chromosome analyses a careful evaluation of prodromal symptoms can help to classify the severity of radiation accidents.
背景
辐射损伤后受害者的伤情分类因剂量值缺失以及大多数组织在潜伏期后才出现反应这一事实而变得复杂。
患者与方法
我们评估了63例在骨髓移植前接受全身照射作为预处理方案的患者，以寻找前驱症状与剂量之间的关系。
结果
辐射暴露后呕吐提示剂量大于1.5戈瑞。暴露后长达5小时体温升至37摄氏度以上与超过2.5戈瑞的剂量有关，而腹泻急性发作是剂量超过9戈瑞的严重事故的一个指标。
结论
除了血细胞计数和染色体分析外，对前驱症状进行仔细评估有助于对辐射事故的严重程度进行分类。
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