Kutyrina I M, Tareeva I E, Shestakova M V, Gerasimenko O I, Zverev K V, Rogov V A, Sheremet'eva O V
Ter Arkh. 1994;66(6):19-22.
Antiproteinuria effects of angiotensin-converting enzyme (ACE) inhibitors was studied in 23 patients with chronic nephritis (CN) and 32 patients with diabetic nephropathy (DN). CN patients received Capoten, DN patients were given enalapril. The drugs were also examined for the action on systemic arterial pressure, renal function and intrarenal hemodynamics. Significantly decreased urinary excretion of protein occurred in DN patients on the treatment month 1, in CN subjects on month 3. In both groups ACE inhibitors produced marked hypotensive effect, did not affect renal function, noticeably improved intraglomerular hemodynamics. Hypotensive and antiproteinuria activity of the drugs were unrelated. The mechanism of antiproteinuria action of ACE inhibitors works via normalization of intrarenal hemodynamics. Systemic arterial hypertension seems to be an additional factor aggravating disturbances of intrarenal circulation and provoking proteinuria.
对23例慢性肾炎（CN）患者和32例糖尿病肾病（DN）患者研究了血管紧张素转换酶（ACE）抑制剂的抗蛋白尿作用。CN患者服用卡托普利，DN患者服用依那普利。还研究了这些药物对体循环动脉血压、肾功能和肾内血流动力学的作用。DN患者在治疗第1个月时尿蛋白排泄显著减少，CN患者在第3个月时减少。在两组中，ACE抑制剂均产生明显的降压作用，不影响肾功能，显著改善肾小球内血流动力学。药物的降压和抗蛋白尿活性无关。ACE抑制剂抗蛋白尿作用的机制是通过使肾内血流动力学正常化发挥作用。体循环动脉高血压似乎是加重肾内循环紊乱和引发蛋白尿的一个额外因素。
