Kutyrina I M, Tareeva I E, Gerasimenko O I, Rogov V A, Miroshnichenko N G
Ter Arkh. 1995;67(5):20-3.
The treatment with inhibitors of angiotensin-converting enzyme (ACE) was conducted in 57 patients with chronic diffuse renal diseases. Of them 45 patients received Capoten, 12 patients Renitek. ACE inhibitors were examined for effects on arterial pressure, proteinuria, renal and intrarenal hemodynamics. A hypotensive effect was apparent in hypertension and minimal in normotension. One month later renal bloodflow increased, glomerular filtration rate did not change. ACE inhibitors proved able to correct intrarenal hypertension: renal functional reserve returned to normal on posttreatment month 1-3 in 10 of 16 patients. Noticeable antiproteinuria effect of the drugs emerged 3 months after the treatment.
对57例慢性弥漫性肾病患者进行了血管紧张素转换酶（ACE）抑制剂治疗。其中45例患者服用卡托普利，12例患者服用雷米普利。研究了ACE抑制剂对动脉血压、蛋白尿、肾和肾内血流动力学的影响。其降压作用在高血压患者中明显，在血压正常者中最小。1个月后肾血流量增加，肾小球滤过率未改变。ACE抑制剂被证明能够纠正肾内高血压：16例患者中有10例在治疗后1 - 3个月肾功能储备恢复正常。治疗3个月后药物出现明显的抗蛋白尿作用。
