Shishkin A N, Ashirova K V, Balliuzek M F, Volovnikova V A
Ter Arkh. 1994;66(6):32-4.
An immunogenetic investigation was conducted of 82 patients with renal disease. 48 of them had nephrotic syndrome (NS) of different origin (glomerulonephritis, amyloidosis, diabetic glomerulosclerosis). The findings were compared to those obtained at control population studies of 619 healthy residents of St. Petersburg. A statistically significant increase in the incidence of HLA antigens A-10, B-13, B-35, B-41, DR-2, DR-7 and high homozygosity were found in NS patients. Antigen A-2 occurred statistically less frequently. A relative risk (RR) to develop the disease was in all cases > 2. Typing of NS patients and those with high diagnostic titers of antistreptolysin-O revealed in them a significantly higher occurrence (r < 0.01) of A-10 and B-40 antigens compared to controls and NS-free patients. HLA antigens appeared related to morphological variants of glomerulonephritis running with NS. The study results suggest association between genetic, etiological factors and body's response to injury. Feasibility of NS prognosis is reviewed.
对82例肾病患者进行了免疫遗传学调查。其中48例患有不同病因（肾小球肾炎、淀粉样变性、糖尿病肾小球硬化症）的肾病综合征（NS）。将这些结果与对圣彼得堡619名健康居民进行的对照人群研究结果进行了比较。发现NS患者中HLA抗原A-10、B-13、B-35、B-41、DR-2、DR-7的发生率及高纯合性有统计学意义的增加。抗原A-2在统计学上出现频率较低。所有病例中患病的相对风险（RR）均>2。对NS患者和抗链球菌溶血素O诊断滴度高的患者进行分型发现，与对照组和无NS患者相比，他们中A-10和B-40抗原的出现频率显著更高（r<0.01）。HLA抗原似乎与伴有NS的肾小球肾炎的形态学变异有关。研究结果提示遗传、病因学因素与机体对损伤的反应之间存在关联。对NS预后的可行性进行了综述。
