Kulaeva N N, Shulutko B I
Ter Arkh. 1994;66(6):37-9.
Distribution of histocompatibility antigens and combinations thereof were investigated in citizens of St. Petersburg. All the examinees suffered from chronic pyelonephritis (CPN). The occurrence of antigens A1 and B17 in the patients was significantly high and associated with increased risk and etiological fraction. Combinations of antigens were frequently encountered in one locus: A1, A2, interlocus combinations A1, B5, A1, B7, A1, B17. Combinations of these antigens (especially A1 + B17) were indicative of high CPN risk. Frequent incidence of antigens A1, B7; A1, B5 may be due to the fact that in the above combinations they are responsible for higher CPN-risk. Increased incidence rate of antigens HLA-A1 and HLA-B17 evidences their involvement into CPN pathogenesis. Strong association of the disease with antigens A1, B17 seems to be typical for St. Petersburg citizens.
对圣彼得堡市民的组织相容性抗原及其组合的分布情况进行了调查。所有受检者均患有慢性肾盂肾炎（CPN）。患者中A1和B17抗原的出现率显著较高，且与风险增加和病因分数相关。抗原组合在一个位点经常出现：A1、A2，位点间组合A1、B5，A1、B7，A1、B17。这些抗原的组合（尤其是A1 + B17）表明CPN风险较高。A1、B7；A1、B5抗原的频繁出现可能是因为在上述组合中它们导致更高的CPN风险。HLA - A1和HLA - B17抗原发生率的增加证明它们参与了CPN的发病机制。该疾病与A1、B17抗原的强关联似乎是圣彼得堡市民的典型特征。
