可诱导型血红素加氧酶人类基因定位于22号染色体q12区。
Mapping of the human gene for inducible heme oxygenase to chromosome 22q12.
作者信息
Kuwano A, Ikeda H, Takeda K, Nakai H, Kondo I, Shibahara S
机构信息
Department of Hygiene, Ehime University School of Medicine.
出版信息
Tohoku J Exp Med. 1994 Apr;172(4):389-92. doi: 10.1620/tjem.172.389.
Heme oxygenase is an essential enzyme in heme catabolism that cleaves heme to form biliverdin, releasing carbon monoxide and iron. There are two isozymes of heme oxygenase: heme oxygenase 1 (HO-1) and heme oxygenase 2, each of which is encoded by a separate gene. It is noteworthy that HO-1 is inducible by various environmental factors, while heme oxygenase 2 is not. Here we have localized the human HO-1 gene to chromosome 22 by polymerase chain reaction (PCR) analysis of human-hamster somatic cell hybrids. The precise region of the HO-1 locus was then determined by fluorescence in situ hybridization, revealing that the human HO-1 gene is localized to 22q12.
血红素加氧酶是血红素分解代谢中的一种关键酶，它可裂解血红素形成胆绿素，释放一氧化碳和铁。血红素加氧酶有两种同工酶：血红素加氧酶1（HO-1）和血红素加氧酶2，它们各自由一个独立的基因编码。值得注意的是，HO-1可被多种环境因素诱导，而血红素加氧酶2则不能。在此，我们通过对人-仓鼠体细胞杂种进行聚合酶链反应（PCR）分析，将人类HO-1基因定位到了22号染色体上。随后通过荧光原位杂交确定了HO-1基因座的精确区域，结果显示人类HO-1基因定位于22q12。
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