Ward P L, Roizman B
Marjorie B. Kovler Viral Oncology Laboratories, University of Chicago, IL 60637.
Trends Genet. 1994 Aug;10(8):267-74. doi: 10.1016/0168-9525(90)90009-u.
The Herpes simplex virus genome encodes 75 proteins. Of these, only 37 are required for growth of the virus in culture. These essential genes encode functions related to entry of virus into cells, regulation of gene expression and replication and packaging of viral DNA into virions. The genes that are not essential for replication in culture play a key role in multiplication of the virus and its transfer from cell to cell, in complementing cellular functions lost as a consequence of viral replication, in fine-tuning viral gene expression and in overcoming the host's response to infection. No virally encoded functions are required for establishment of the latent state, but a full complement of viral genes is essential for efficient reactivation of the virus from the latent state.
单纯疱疹病毒基因组编码75种蛋白质。其中，只有37种是病毒在培养物中生长所必需的。这些必需基因编码的功能与病毒进入细胞、基因表达调控、病毒DNA复制以及包装进病毒粒子有关。在培养物中复制非必需的基因在病毒增殖及其细胞间转移、补充因病毒复制而丧失的细胞功能、微调病毒基因表达以及克服宿主对感染的反应中起关键作用。建立潜伏状态不需要病毒编码的功能，但完整的病毒基因对于病毒从潜伏状态有效重新激活至关重要。
