Albonico M, Renganathan E, Bosman A, Kisumku U M, Alawi K S, Savioli L
Programme of Intestinal Parasitic Infections, World Health Organization, Geneva, Switzerland.
Trop Geogr Med. 1994;46(3):142-6.
The efficacy of a single-dose of mebendazole to treat intestinal helminths was studied in Pemba Island, Zanzibar, with the view of incorporating it in future control programmes. A single Kato-Katz stool examination was performed on 2,269 individuals from all age groups. 1,883 individuals were treated with 500 mg of mebendazole (250 mg for children below two years) and re-examined one month and four months after therapy. A total of 466 presented themselves for all three surveys and the data has been reported in this study. The overall cure rate for ascariasis was 93.2% and reduction of egg load after treatment was 89.8% in persistent positive cases. Although the cure rates were lower in trichuriasis (25.6%) and hookworm (17.8%) infections, egg reduction was more evident with 47% for Trichuris trichiura and 51.9% for hookworms. A single dose of mebendazole results not only in a high cure rate for ascariasis but also in a decrease in intensity of ascariasis, trichuriasis and hookworm infections, thereby contributing to its incorporation into low-budget control programmes in developing countries.
在桑给巴尔的奔巴岛研究了单剂量甲苯达唑治疗肠道蠕虫的疗效，目的是将其纳入未来的控制计划。对来自所有年龄组的2269人进行了一次加藤-卡茨粪便检查。1883人接受了500毫克甲苯达唑治疗（两岁以下儿童为250毫克），并在治疗后1个月和4个月进行复查。共有466人参加了所有三次调查，本研究报告了相关数据。蛔虫病的总体治愈率为93.2%，持续阳性病例治疗后虫卵负荷减少89.8%。虽然鞭虫病（25.6%）和钩虫病（17.8%）感染的治愈率较低，但虫卵减少更为明显，鞭虫为47%，钩虫为51.9%。单剂量甲苯达唑不仅能使蛔虫病获得高治愈率，还能降低蛔虫病、鞭虫病和钩虫感染的强度，因此有助于将其纳入发展中国家的低成本控制计划。
