对一只犬和一只猫身上的两例牙源性钙化上皮瘤（CEOT）进行光镜、超微结构及免疫组织化学检查。

Light microscopic, ultrastructural, and immunohistochemical examinations of two calcifying epithelial odontogenic tumors (CEOT) in a dog and a cat.

作者信息

Breuer W, Geisel O, Linke R P, Hermanns W

机构信息

Institute of Veterinary Pathology, University of Munich, Germany.

出版信息

Vet Pathol. 1994 Jul;31(4):415-20. doi: 10.1177/030098589403100402.

DOI:10.1177/030098589403100402

PMID:7941229

Abstract

Two calcifying epithelial odontogenic tumors from a 10-year-old cross-breed dog and a 9-year-old cat were characterized histologically and electron microscopically. Important characteristics were plexiform to squamous epithelial structure, amyloid in the tumor tissue with partial calcification (Liesegang's rings), and a low rate of mitosis. The amyloid found in the tumors was subjected to immunohistochemical examination, using a series of antibodies (anti-AA, -AL, -AF, -ASc1, -AB, -cytokeratin, -vimentin, -desmin, -laminin). The exclusive reaction to anti-cytokeratin and anti-laminin suggests that the amyloid is of epithelial origin.

摘要

对一只10岁杂种犬和一只9岁猫身上的两颗钙化上皮性牙源性肿瘤进行了组织学和电子显微镜特征分析。重要特征包括丛状至鳞状上皮结构、肿瘤组织中存在淀粉样物质并伴有部分钙化（莱氏环）以及有丝分裂率低。对肿瘤中发现的淀粉样物质使用一系列抗体（抗AA、抗AL、抗AF、抗ASc1、抗AB、抗细胞角蛋白、抗波形蛋白、抗结蛋白、抗层粘连蛋白）进行免疫组化检查。对抗细胞角蛋白和抗层粘连蛋白的唯一反应表明该淀粉样物质起源于上皮。