Sigmund M, van Erckelens F, Reupcke C, Heiermann B, Hanrath P
Medizinische Klinik I, RWTH Aachen.
Z Kardiol. 1994;83 Suppl 3:145-8.
This study used ergospirometry with quantification of gas exchange parameters to analyze the beneficial effects of two sensors for rate responsive pacing: QT-interval and minute ventilation (MV). Bicycle exercise testing was performed with modulating VVIR pacing modes in random sequence. Rate responsiveness effected a mean increase of exercise tolerance of 31.1% in the QT group and 22.6% in the MV group. With both systems maximal oxygen uptake increased by 29.4% (QT) and 28.3% (MV). Oxygen consumption at the anaerobic threshold was improved by 28.3% (QT) and 32.1% (MV). The increase of cardiopulmonary parameters achieved by rate responsiveness was significant (p < 0.05) without significant difference in comparison between both groups. Despite the initially delayed rate increase at the onset of exercise mediated by the QT-interval, the programmed upper rate limit was satisfactorily attained by both principles. Thus, both sensors--minute ventilation and QT-interval--provide an adequate rate modulation in response to exercise and a marked improvement of cardiopulmonary work capacity.
本研究采用运动气体代谢测定法并对气体交换参数进行量化，以分析两种用于频率应答性起搏的传感器的有益效果：QT间期和分钟通气量（MV）。以随机顺序调节VVIR起搏模式进行自行车运动测试。频率应答性使QT组的运动耐量平均增加31.1%，MV组增加22.6%。使用这两种系统时，最大摄氧量分别增加了29.4%（QT）和28.3%（MV）。无氧阈时的耗氧量分别提高了28.3%（QT）和32.1%（MV）。频率应答性实现的心肺参数增加具有显著性（p < 0.05），两组之间比较无显著差异。尽管最初由QT间期介导的运动开始时频率增加延迟，但两种原理均能令人满意地达到设定的上限频率。因此，分钟通气量和QT间期这两种传感器均能根据运动提供适当的频率调节，并显著改善心肺工作能力。
