[口服避孕药对乳腺癌增殖活性的影响]
[Effect of oral contraceptives on the proliferative activity of breast cancer].
作者信息
Schönborn I, Minguillon C, Möhner M
机构信息
Frauenklinik Universitätsklinikum Rudolf Virchow, Standort Charlottenburg, Freie Universität, Berlin.
出版信息
Zentralbl Gynakol. 1994;116(7):385-9.
In 471 breast cancer patients the possible influence of an antecedent oral contraceptive (OC) use on proliferative activity (PCNA-expression) of mammary carcinomas was investigated. PCNA-expression (Proliferating Cell Nuclear Antigen) was immunohistochemically assessed using formalin-fixed, paraffin-embedded tissue. PCNA-expression discriminated tumors of low (< 20%) and increased (> or = 20%) proliferative fractions. 297 (63%) patients had ever used OCs and 202 (43%) of them were long-term users (> or = 49 months). Age adjusted proliferative fractions showed no statistically significant differences dependent on duration of OC use (never, 1-48 months, > or = 49 months), despite a slightly higher frequency of tumors with an increased PCNA-expression in ever users of OCs (p = 0.125).
在471例乳腺癌患者中，研究了既往口服避孕药（OC）的使用对乳腺癌增殖活性（PCNA表达）的可能影响。使用福尔马林固定、石蜡包埋的组织，通过免疫组织化学方法评估PCNA表达（增殖细胞核抗原）。PCNA表达区分了增殖分数低（<20%）和增加（≥20%）的肿瘤。297例（63%）患者曾使用过OC，其中202例（43%）为长期使用者（≥49个月）。尽管曾经使用OC的患者中PCNA表达增加的肿瘤频率略高（p = 0.125），但年龄校正后的增殖分数并未显示出依赖于OC使用持续时间（从未使用、1 - 48个月、≥49个月）的统计学显著差异。
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