Migunov V N, Pozina I M, Levina L A, Chulok T A, Severtseva M K, Minakova L V, Temper R M, Klimova Z V
Zh Mikrobiol Epidemiol Immunobiol. 1994 May-Jun(3):88-92.
The antigen-binding activity of commercial preparations of immunoglobulin with different molecular composition was studied in the enzyme immunoassay with Escherichia coli lipopolysaccharide and serogroup B Neisseria meningitidis protein antigen. Immunoglobulin preparations for intramuscular injection were found to possess higher specific antigen-binding activity than immunoglobulin preparations for intravenous injection, which was determined by both the presence of the highly active polymer and dimer fractions and greater specific activity of the monomer fraction. A group of intramuscular immunoglobulin preparations with a considerable content of polymers were found to have significantly greater specific activity than a group of preparations containing small amounts of polymers.
采用酶免疫分析法，以大肠杆菌脂多糖和B群脑膜炎奈瑟菌蛋白抗原为对象，研究了不同分子组成的免疫球蛋白商业制剂的抗原结合活性。结果发现，肌内注射用免疫球蛋白制剂比静脉注射用免疫球蛋白制剂具有更高的特异性抗原结合活性，这是由高活性聚合物和二聚体组分的存在以及单体组分更高的比活性所决定的。还发现，一组聚合物含量可观的肌内免疫球蛋白制剂的比活性明显高于一组聚合物含量少的制剂。
