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[脑血管疾病中儿茶酚胺代谢的病理学]

[The pathology of catecholamine metabolism in cerebrovascular diseases].

作者信息

Barkhatova V P, Varakin Iu Ia, Suslina Z A, Demina E G, Gornostaeva G V, Faĭnberg G F

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 1994;94(2):33-7.

PMID:7941886
Abstract

Blood catecholamines were investigated with high-performance liquid chromatography and electrochemical detection in 95 patients with cerebrovascular affections. On day 1-3 since ischemic apoplexy blood norepinephrine and dopamine levels increased significantly. This is possibly due to their active release from neurons in brain tissue ischemia. High blood catecholamines are thought an unfavourable factor aggravating the disease and responsible for cardiac sequelae. Ways of cerebral tissue protection in case of ischemia are suggested.

摘要

采用高效液相色谱法和电化学检测法对95例脑血管疾病患者的血儿茶酚胺进行了研究。在缺血性中风后的第1至3天,血去甲肾上腺素和多巴胺水平显著升高。这可能是由于它们在脑组织缺血时从神经元中主动释放所致。血儿茶酚胺水平升高被认为是加重病情的不利因素,并与心脏后遗症有关。文中提出了缺血时脑组织保护的方法。

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