Obata H, Horiuchi H, Miyata K, Tsuru T, Machinami R
Department of Pathology, Faculty of Medicine, University of Tokyo, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Aug;98(8):765-71.
We investigated histopathological changes in human meibomian glands and analyzed the incidence of histopathological parameters and the relationship between parameters and age or sex of patients. Human meibomian glands, measuring 3 x 3 mm in size, were excised from both upper eyelids of 72 autopsy cases (mean age 63 +/- 12 years; 44 males, 28 females). The specimens were stained with hematoxylin and eosin and examined in detail with the light microscope. The following histopathological changes were investigated as parameters: (1) cystic dilatation of the duct and/or the acini, (2) atrophy of the acini, and (3) granulomatous inflammation. The incidences of the parameters were (1) 34.7% (25 cases), (2) 19.4% (14 cases), and (3) 18.6% (13 cases). There was statistically significant correlation between age and atrophy of the acini, which was found in the older patients. No sex difference was found in any of the parameters. These results suggest that the decrease in the meibomian gland secretion with aging is related to atrophy of the acini. These results further suggest that cystic dilatation, which has been described as a histopathological finding in meibomian gland dysfunction, may be caused by factors other than aging.
我们研究了人类睑板腺的组织病理学变化，分析了组织病理学参数的发生率以及这些参数与患者年龄或性别的关系。从72例尸检病例（平均年龄63±12岁；男性44例，女性28例）的上眼睑切除大小为3×3毫米的人类睑板腺。标本用苏木精和伊红染色，并用光学显微镜进行详细检查。以下组织病理学变化作为参数进行研究：（1）导管和/或腺泡的囊性扩张，（2）腺泡萎缩，（3）肉芽肿性炎症。这些参数的发生率分别为：（1）34.7%（25例），（2）19.4%（14例），（3）18.6%（13例）。年龄与腺泡萎缩之间存在统计学上的显著相关性，这种情况在老年患者中更为常见。在任何参数中均未发现性别差异。这些结果表明，睑板腺分泌随年龄增长而减少与腺泡萎缩有关。这些结果进一步表明，在睑板腺功能障碍中被描述为组织病理学表现的囊性扩张，可能是由衰老以外的因素引起的。
