Berhe N, Ali A, Hailu A, Yeneneh H
Institute of Pathobiology (IPB), Addis Ababa University (AAU), Ethiopia.
Acta Trop. 1994 Jun;57(1):83-90. doi: 10.1016/0001-706x(94)90096-5.
Relapse after chemotherapy using the pentavalent antimonials, sodium stibogluconate and meglumine antimoniate, was assessed in 135 patients diagnosed in the Aba Roba focus of south western Ethiopia during the period 1982-1991. Ten cases relapsed with a mean of 15.6 +/- 16.3 months following treatment. A 15-day course of 10 mg Sbv/kg b.wt. sodium stibogluconate used in 1982/1983 had a better outcome than a 15-day course of 17 mg Sbv/kg b.wt. of meglumine antimoniate used in 1990/1991. The relapse rate among patients treated with sodium stibogluconate 16-20 mg Sbv/kg b.wt. for 20 days in 1985-1990 was comparable to the relapse rate in patients treated with meglumine antimoniate 16-20 mg Sbv/kg b.wt. for 20 days in 1990/1991. Findings are discussed.
1982年至1991年期间，在埃塞俄比亚西南部的阿巴罗巴疫区，对135例确诊患者使用五价锑化合物（葡甲胺锑酸钠和葡糖酸锑钠）进行化疗后的复发情况进行了评估。10例患者复发，治疗后平均复发时间为15.6±16.3个月。1982/1983年使用的10毫克锑元素/千克体重的葡糖酸锑钠进行15天疗程的治疗效果，优于1990/1991年使用的17毫克锑元素/千克体重的葡甲胺锑酸钠进行15天疗程的治疗效果。1985 - 1990年使用16 - 20毫克锑元素/千克体重的葡糖酸锑钠进行20天疗程治疗的患者复发率，与1990/1991年使用16 - 20毫克锑元素/千克体重的葡甲胺锑酸钠进行20天疗程治疗的患者复发率相当。对研究结果进行了讨论。
