Ohnishi N, Kishima Y, Hashimoto K, Kiwamoto H, Esa A, Sugiyama T, Park Y C, Kurita T
Department of Urology, Kinki University School of Medicine.
Hinyokika Kiyo. 1994 Aug;40(8):657-61.
Low compliant bladder is an important cause of detrusor dysfunction, although its cause is unknown. Two groups of patients who developed low compliant bladder have been studied by the morphometric technique. One group consisted of patients with neurogenic low compliant bladder, and the other group consisted of patients with non-neurogenic low compliant bladder. Control materials were obtained from postmortal samples offered from the department of anatomy. Bladder wall samples were obtained during bladder augmentation surgery. Morphometric computer analysis was used to measure the proportions of connective tissue and muscle layer in the bladder wall samples. In the non-neurogenic group, there was a significant increase in connective tissue and a marked decrease in muscle layer proportion than the control group. On the other hand, there was a mild increase in connective tissue, but no decrease in muscle layer proportion was observed in patients with neurogenic low compliant bladder. Comparison of the results obtained from the two groups suggested that low bladder compliance in neurogenic patients is mainly caused by functional alteration of the bladder wall, whereas that in non-neurogenic patients is caused by an organic change of the bladder wall.
顺应性降低的膀胱是逼尿肌功能障碍的一个重要原因，尽管其病因尚不清楚。已通过形态测量技术对两组出现顺应性降低膀胱的患者进行了研究。一组由神经源性顺应性降低膀胱患者组成，另一组由非神经源性顺应性降低膀胱患者组成。对照材料取自解剖学系提供的尸检样本。膀胱壁样本在膀胱扩大手术期间获取。采用形态测量计算机分析来测量膀胱壁样本中结缔组织和肌肉层的比例。在非神经源性组中，与对照组相比，结缔组织显著增加，肌肉层比例显著降低。另一方面，在神经源性顺应性降低膀胱患者中，结缔组织有轻度增加，但未观察到肌肉层比例降低。两组结果的比较表明，神经源性患者膀胱顺应性降低主要由膀胱壁的功能改变引起，而非神经源性患者则由膀胱壁的器质性改变引起。
