Obarzanek E, Lesem M D, Jimerson D C
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
Am J Clin Nutr. 1994 Nov;60(5):666-75. doi: 10.1093/ajcn/60.5.666.
To determine whether changes in energy metabolism may contribute to the difficulty of weight gain observed in anorexic patients, resting metabolic rate (RMR) and neuroendocrine function were studied in 10 patients diagnosed with anorexia nervosa. RMR per kilogram lean body mass (+/- SEM) was not significantly different from that of healthy volunteers on admission (95.9 +/- 5.6 vs 103.6 +/- 3.3 kJ/kg, respectively), during early refeeding (108.6 +/- 6.9 kJ/kg), or at target weight (102.1 +/- 3.8 kJ/kg). At late refeeding RMR was significantly higher (132.1 +/- 4.9 kJ/kg, P < 0.0001). There were no significant correlations between plasma norepinephrine and thyroid hormones and RMR. The rise in RMR during refeeding is at least double that observed in other studies in which normal-weight subjects are experimentally overfed or experimentally underfed and then refed. These results suggest that the increase in RMR during refeeding is disproportionate to weight gain and this large magnitude of increase may be unique to anorexia nervosa.
为了确定能量代谢的变化是否可能导致厌食症患者体重增加困难，我们对10名被诊断为神经性厌食症的患者进行了静息代谢率（RMR）和神经内分泌功能研究。入院时、早期再喂养期间或达到目标体重时，每千克瘦体重的RMR（±标准误）与健康志愿者相比无显著差异（分别为95.9±5.6 vs 103.6±3.3 kJ/kg）。在后期再喂养时，RMR显著升高（132.1±4.9 kJ/kg，P<0.0001）。血浆去甲肾上腺素和甲状腺激素与RMR之间无显著相关性。再喂养期间RMR的升高至少是其他研究中观察到的两倍，在其他研究中，正常体重受试者被实验性过度喂养或实验性喂养不足然后再喂养。这些结果表明，再喂养期间RMR的增加与体重增加不成比例，这种大幅增加可能是神经性厌食症所特有的。
