Pirisi M, Falleti E, Fabris C, Soardo G, Toniutto P, Vitulli D, Pezzetta F, Bortolotti N, Gonano F, Bartoli E
Cattedra di Medicina Interna, Università degli Studi, Udine, Italy.
Am J Clin Pathol. 1994 Nov;102(5):600-4. doi: 10.1093/ajcp/102.5.600.
The authors measured immunoenzymatically circulating intercellular adhesion molecule-1 (cICAM-1) concentration in 135 patients with liver disease of either viral or toxic etiology: 13 had acute hepatitis; 58 had mild chronic liver disease; and 64 had cirrhosis (superimposed in 30 by hepatocellular carcinoma). Forty patients with extrahepatic diseases (19 with malignancies) and 28 healthy blood donors were tested as controls. One-way analysis of variance demonstrated a significant variability of cICAM-1 concentration among groups (F = 76.67, P < .0001), the highest value being recorded in acute hepatitis (Bonferroni's test for pairwise comparisons, P < .01). Total bilirubin showed a strong correlation with cICAM-1 (R = 0.766, P < .001). By stepwise multiple regression analysis the independent predictors of cICAM-1 concentration were chosen in the following order: total bilirubin; aspartate aminotransferase; cholinesterase; alpha-1-antitrypsin; and immunoglobulins. Thus, in addition to inflammation, cholestasis and decline of functioning hepatic mass may influence cICAM-1 concentration.
作者采用免疫酶法检测了135例病毒性或中毒性病因所致肝病患者循环中细胞间黏附分子-1（cICAM-1）的浓度：13例为急性肝炎；58例为轻度慢性肝病；64例为肝硬化（其中30例合并肝细胞癌）。40例肝外疾病患者（19例为恶性肿瘤患者）和28名健康献血者作为对照。单因素方差分析显示各组间cICAM-1浓度存在显著差异（F = 76.67，P <.0001），急性肝炎组cICAM-1浓度最高（两两比较的Bonferroni检验，P <.01）。总胆红素与cICAM-1呈强相关（R = 0.766，P <.001）。通过逐步多元回归分析，按以下顺序选择了cICAM-1浓度的独立预测因素：总胆红素；天冬氨酸转氨酶；胆碱酯酶；α-1抗胰蛋白酶；以及免疫球蛋白。因此，除炎症外，胆汁淤积和肝实质功能下降可能影响cICAM-1浓度。
