Neri M, Susi D, Bovani I, Laterza F, Mezzetti A, Cuccurullo F
Department of Gastroenterology, S. Timoteo Hospital, Termoli, Italy.
Am J Gastroenterol. 1994 Oct;89(10):1801-5.
We wished to demonstrate that gastric epithelial cells infiltration by HP is associated with the active inflammatory response and the severity of gastritis in the gastric antrum of patients harboring the bacterium.
We studied 129 patients with HP-associated gastritis and 60 HP-negative controls with gastritis of different origin. Gastric mucosal biopsies were obtained from all subjects at endoscopy and were examined for histological features of active inflammation and type of gastritis, as well as for electronmicroscopical features of invasion and damage, according to a four-degree classification (range 0-3).
At entry, the presence of acute inflammatory activity, defined according to the presence of a polymorphonuclear cell infiltrate, was significantly greater in HP-positive patients than in controls (p < 0.00001) and was well related to the depth of mucosal invasion (p < 0.001). Accordingly, the prevalence of chronic atrophic gastritis was higher in HP-positive patients (p < 0.02 vs. controls) and at grade 3 of invasion (p < 0.04 vs. grade 1 and 2). Peptic ulcers were more frequent in grade 3 patients (p < 0.04).
Gastric epithelial cell infiltration and damage by HP, as assessed by electron microscopy, is an important feature of HP-associated gastritis due to its histological and clinical correlates.
我们希望证明幽门螺杆菌（HP）对胃上皮细胞的浸润与携带该细菌患者胃窦部的活动性炎症反应及胃炎严重程度相关。
我们研究了129例幽门螺杆菌相关性胃炎患者和60例不同病因的非幽门螺杆菌感染性胃炎对照者。在内镜检查时从所有受试者获取胃黏膜活检组织，并根据四度分类法（范围0 - 3）检查活动性炎症的组织学特征、胃炎类型以及浸润和损伤的电子显微镜特征。
初始时，根据多形核细胞浸润情况定义的急性炎症活动在幽门螺杆菌阳性患者中显著高于对照组（p < 0.00001），且与黏膜浸润深度密切相关（p < 0.001）。相应地，幽门螺杆菌阳性患者中慢性萎缩性胃炎的患病率更高（与对照组相比，p < 0.02），在浸润3级时更高（与1级和2级相比，p < 0.04）。消化性溃疡在3级患者中更常见（p < 0.04）。
通过电子显微镜评估，幽门螺杆菌对胃上皮细胞的浸润和损伤因其组织学和临床相关性，是幽门螺杆菌相关性胃炎的一个重要特征。
