Veugelers P J, Page K A, Tindall B, Schechter M T, Moss A R, Winkelstein W W, Cooper D A, Craib K J, Charlebois E, Coutinho R A
Municipal Health Service, Department of Public Health, Amsterdam, The Netherlands.
Am J Epidemiol. 1994 Oct 15;140(8):747-58. doi: 10.1093/oxfordjournals.aje.a117322.
Data on 403 homosexual/bisexual men with documented dates of human immunodeficiency virus (HIV) seroconversion were merged. All subjects originated from cohort studies that started between 1982 and 1984 in Amsterdam, The Netherlands; San Francisco, California; Sydney, Australia; and Vancouver, British Columbia, Canada. With respect to the four geographic locations, no statistically significant differences in progression time from HIV seroconversion to acquired immunodeficiency syndrome (AIDS) and death as well as in AIDS diagnoses patterns could be demonstrated. The median time from HIV seroconversion to AIDS was 8.3 years, that from HIV seroconversion to death was 8.9 years, and that from AIDS to death was 17 months. The authors evaluated HIV disease progression with respect to demographic, clinical, and behavioral cofactors. Younger age and use of prophylaxis against Pneumocystis carinii pneumonia were significantly related to slower progression from seroconversion to death. In addition, an association between slower progression and earlier dates of seroconversion was found. No relation of sexual behavior; history of sexually transmitted diseases; or use of alcohol, tobacco, and recreational drugs with rates of disease progression could be demonstrated.
合并了403名有记录的人类免疫缺陷病毒（HIV）血清转化日期的同性恋/双性恋男性的数据。所有受试者均来自于1982年至1984年期间在荷兰阿姆斯特丹、美国加利福尼亚州旧金山、澳大利亚悉尼和加拿大不列颠哥伦比亚省温哥华开展的队列研究。就这四个地理位置而言，从HIV血清转化到获得性免疫缺陷综合征（AIDS）和死亡的进展时间以及AIDS诊断模式方面，未显示出统计学上的显著差异。从HIV血清转化到AIDS的中位时间为8.3年，从HIV血清转化到死亡的中位时间为8.9年，从AIDS到死亡的中位时间为17个月。作者评估了HIV疾病进展与人口统计学、临床和行为协变量的关系。较年轻的年龄以及使用卡氏肺孢子虫肺炎预防措施与从血清转化到死亡的进展较慢显著相关。此外，发现进展较慢与血清转化日期较早之间存在关联。未显示性行为、性传播疾病史或酒精、烟草及消遣性药物的使用与疾病进展速率之间存在关联。
