可卡因会改变胎盘血栓素和前列环素的生成。

Cocaine alters placental production of thromboxane and prostacyclin.

作者信息

Monga M, Chmielowiec S, Andres R L, Troyer L R, Parisi V M

机构信息

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston 77030.

出版信息

Am J Obstet Gynecol. 1994 Oct;171(4):965-9. doi: 10.1016/0002-9378(94)90015-9.

DOI:10.1016/0002-9378(94)90015-9

PMID:7943110

Abstract

OBJECTIVE

The objective of this study was to test the hypothesis that cocaine alters placental prostaglandin production in vitro.

STUDY DESIGN

Placentas were obtained from healthy women (n = 6) after normal vaginal delivery at term. Placental explants (300 mg) were incubated in duplicate at 37 degrees C in the presence of 0, 30, 300, or 3000 ng/ml cocaine. Thromboxane and prostacyclin production was measured by radioimmunoassay of their stable metabolites (thromboxane B2 and 6-keto-prostaglandin F1 alpha) at 0, 0.5, 1.0, 1.5, 2, 4, 8, and 12 hours. Analysis of variance with Newman-Keuls test was used for statistical analysis.

RESULTS

Cocaine increased thromboxane production in a dose-dependent manner (p < 0.001) and decreased prostacyclin production (p < 0.05). Cocaine increased the ratio of thromboxane/prostacyclin production (p < 0.05).

CONCLUSION

Cocaine alters the placental production of prostaglandins in vitro, favoring thromboxane production, which may cause vasoconstriction and decrease uteroplacental blood flow.

摘要

目的

本研究的目的是检验可卡因在体外改变胎盘前列腺素生成的假说。

研究设计

足月正常阴道分娩后从健康女性（n = 6）获取胎盘。将胎盘外植体（300毫克）一式两份在37摄氏度下于0、30、300或3000纳克/毫升可卡因存在的情况下孵育。在0、0.5、1.0、1.5、2、4、8和12小时通过对其稳定代谢产物（血栓素B2和6-酮-前列腺素F1α）进行放射免疫测定来测量血栓素和前列环素的生成。采用方差分析和纽曼-基尔斯检验进行统计分析。