Hung K L, Wang H S, Liou W Y, Mak S C, Chi C S, Shen E Y, Lin M I, Wang P J, Shen Y Z, Chang K P
Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan, ROC.
Brain Dev. 1994 May-Jun;16(3):204-8. doi: 10.1016/0387-7604(94)90070-1.
Seventy-two children with Guillain-Barré syndrome (GBS), diagnosed at 11 major teaching hospitals in Taiwan during the period 1986-1990, were studied retrospectively. There were 44 males and 28 females ranging in age from 7 months to 15 years. Preceding events could be traced in 61 patients (85%), including antecedent infection in 59 patients and previous vaccination in 2. As well as the consistent pictures of progressive weakness and generalized hyporeflexia, there were sensory complaints (26%), cranial nerve lesions (46%), respiratory failure (14%) and autonomic dysfunction (25%). Motor symptoms reached a maximum within 20 days in 88% of the patients, with the plateau lasting less than 2 weeks in 75%, and became stable within 3 months in 76%. Overall outcome showed complete recovery in 73% of the patients within 6 months after onset. Four (5.6%) had recurrence, and there was no mortality. The present study revealed that the annual incidence of GBS in Taiwan can be estimated roughly as 0.66 per 100,000 and that the course of childhood GBS is relatively benign.
对1986年至1990年期间在台湾11家主要教学医院确诊的72例吉兰-巴雷综合征（GBS）患儿进行了回顾性研究。其中男性44例，女性28例，年龄从7个月至15岁不等。61例（85%）患儿可追溯到前驱事件，其中59例有前驱感染，2例有既往疫苗接种史。除了进行性肌无力和全身性反射减退的典型表现外，还有感觉障碍（26%）、脑神经损害（46%）、呼吸衰竭（14%）和自主神经功能障碍（25%）。88%的患儿运动症状在20天内达到高峰，75%的患儿平台期持续不到2周，76%的患儿在3个月内病情稳定。总体结果显示，73%的患儿在发病后6个月内完全康复。4例（5.6%）复发，无死亡病例。本研究表明，台湾GBS的年发病率约为每10万人口0.66例，儿童GBS的病程相对良性。
