Kusakabe H, Yonebayashi K, Sakatani S, Iki M, Nakasuji K, Kiyokane K, Yasuhara M, Nakagawa J, Mori H
Department of Dermatology, Osaka Medical College, Japan.
Am J Dermatopathol. 1994 Jun;16(3):294-300. doi: 10.1097/00000372-199406000-00012.
At age 25 a Japanese woman noticed an elastic-hard nodule 2 cm in diameter on the anterior side of her right leg. The nodule had developed an ulcer in its center. Simple resection was performed several times. However, the lesion recurred repeatedly. The patient underwent amputation of the right leg at the age of 34, because the diagnosis of epithelioid sarcoma was established histologically. No recurrence was observed for 9 years. Recently, the patient noticed multiple painful, ulcerative nodules about 1 cm in diameter on her scalp, trunk, and extremities. She refused extensive resection for a religious reason and died of massive hematemesis. Autopsy revealed metastatic epithelioid sarcoma in the skin, lungs, kidneys, pancreas, transverse colon, thyroid, and sternum. Chromosomal analysis of the tumor revealed various aberrations and an N-ras oncogene mutation.
一名25岁的日本女性注意到其右腿前侧有一个直径2厘米的质地硬且有弹性的结节。该结节中央出现了溃疡。多次进行了单纯切除术。然而，病变反复复发。患者在34岁时接受了右腿截肢手术，因为组织学诊断为上皮样肉瘤。9年内未观察到复发。最近，患者注意到其头皮、躯干和四肢出现多个直径约1厘米的疼痛性溃疡性结节。她因宗教原因拒绝广泛切除，最终死于大量呕血。尸检显示皮肤、肺、肾、胰腺、横结肠、甲状腺和胸骨有转移性上皮样肉瘤。对肿瘤进行染色体分析发现了各种畸变以及N-ras癌基因突变。
