[Assessment of reperfusion damage to the myocardium by oxygen free radicals in patients with ischemic heart disease subjected to surgery with artificial blood circulation].

The study was performed on 47 patients with ischemic heart disease subjected to aortocoronary bypass surgery. The study has revealed adaptation changes of free-radical blood properties that led to the damage of the myocardium by oxygen free radicals. Blood sampling from the coronary sinus is of greatest diagnostic value, enhancement of antiradical properties of this blood indicate damage of the myocardium. Detection of lactate in coronary blood may be an early sign of hypoxic myocardial damage caused among other reasons by activation of free-radical processes. Abrupt changes from hypoxic to hyperoxic oxygenation may complicate the recovery of cardiac function, while an even regimen of oxygen supply with a certain tendency of hyperoxia and adequate myocardial protection will not promote damage of the myocardium.