Golub I E, Iaverbaum I M, Galeeva O P
Anesteziol Reanimatol. 1993 May-Jun(3):18-21.
The effect of general anesthesia with ether, azeotropic mixture and drugs for neuroleptanalgesia on the activity of glycolytic enzymes and the content of glycolysis metabolites in erythrocytes has been studied in 212 patients with II to IV stage gastric cancer. It has been shown that ether anesthesia and anesthesia with azeotropic mixture aggravate metabolic disturbances, while neuroleptanalgesia has no negative effect on cellular metabolism. The absence of correlation between the severity of surgical intervention and the degree of disturbances in erythrocyte metabolism indicates a sufficient anesthesiological protection when drugs for neuroleptanalgesia are used.
对212例II至IV期胃癌患者研究了乙醚全身麻醉、共沸混合物麻醉和神经安定镇痛药物对红细胞糖酵解酶活性及糖酵解代谢产物含量的影响。结果表明，乙醚麻醉和共沸混合物麻醉会加重代谢紊乱，而神经安定镇痛对细胞代谢无负面影响。手术干预的严重程度与红细胞代谢紊乱程度之间缺乏相关性，这表明使用神经安定镇痛药物时具有充分的麻醉保护作用。
